Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

BACKGROUND: HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such as DCAF1-Cul4A E3 ligase complex) to target ma...

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Publicat a:J Transl Med
Autors principals: Eldin, Patrick, Péron, Sophie, Galashevskaya, Anastasia, Denis-Lagache, Nicolas, Cogné, Michel, Slupphaug, Geir, Briant, Laurence
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418440/
https://ncbi.nlm.nih.gov/pubmed/32778120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02478-7
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