Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect

It was recently reported that human immunodeficiency virus type 1 (HIV-1) Vpr induced the proteasomal degradation of the nuclear UNG2 enzyme for efficient virus replication. We confirm here that HIV-1 infection and Vpr expression reduce the level of endogenous UNG2, but this effect is not reverted b...

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Détails bibliographiques
Auteurs principaux: Langevin, Christelle, Maidou-Peindara, Priscilla, Aas, Per Arne, Jacquot, Guillaume, Otterlei, Marit, Slupphaug, Geir, Benichou, Serge
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748015/
https://ncbi.nlm.nih.gov/pubmed/19625402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02654-08
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