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Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model
Hyperphosphorylated and truncated tau variants are enriched in neuropathological aggregates in diseases known as tauopathies. However, whether the interaction of these posttranslational modifications affects tau toxicity as a whole remains unresolved. By expressing human tau with disease-related Ser...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7417559/ https://ncbi.nlm.nih.gov/pubmed/32778728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70423-1 |
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