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Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

TAU mutations are genetically linked to fronto-temporal dementia (FTD) and hyper-phosphorylated aggregates of Tau form neurofibrillary tangles (NFTs) that constitute a pathological hallmark of Alzheimer disease (AD) and FTD. These observations indicate that Tau has a pivotal role in the pathogenesis...

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Enregistré dans:
Détails bibliographiques
Publié dans:Transl Psychiatry
Auteurs principaux: Biundo, F, d'Abramo, C, Tambini, M D, Zhang, H, Del Prete, D, Vitale, F, Giliberto, L, Arancio, O, D'Adamio, L
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611732/
https://ncbi.nlm.nih.gov/pubmed/28786980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.165
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