Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models

With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD), immunotherapy has emerged as a potential disease-modifying strategy to target tau. Many studies have proven effective to clear pathological tau specie...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Vitale, Francesca, Ortolan, Jasmin, Volpe, Bruce T., Marambaud, Philippe, Giliberto, Luca, d’Abramo, Cristina
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409655/
https://ncbi.nlm.nih.gov/pubmed/32762731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01003-7
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