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Methods for Measuring Tau Pathology in Transgenic Mouse Models
In Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, undergoes a conformational change, and becomes aggregated and insoluble. There are three methods commonly used to study the insoluble tau fraction, two that utilize detergents (Sarkosyl and RIPA) and another that does not...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627375/ https://ncbi.nlm.nih.gov/pubmed/22976073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-121354 |
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