Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction

Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer’s disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I mediates both tau phosphorylation and synaptic dysfunction in...

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Опубликовано в: :eLife
Главные авторы: Zhang, Xingyu, Zou, Li, Meng, Lanxia, Xiong, Min, Pan, Lina, Chen, Guiqin, Zheng, Yongfa, Xiong, Jing, Wang, Zhihao, Duong, Duc M, Zhang, Zhaohui, Cao, Xuebing, Wang, Tao, Tang, Li, Ye, Keqiang, Zhang, Zhentao
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2021
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139826/
https://ncbi.nlm.nih.gov/pubmed/34018922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65301
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