C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

A hexanucleotide repeat expansion in C90RF72 is the most common genetic variant contributing to Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)(1,2). The C90RF72 mutation acts through gain and loss of function mechanisms to induce pathways implicated in neural degeneration(3–9)...

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Publicado no:Nature
Main Authors: Burberry, Aaron, Wells, Michael F., Limone, Francesco, Couto, Alexander, Smith, Kevin S., Keaney, James, Gillet, Gaëlle, van Gastel, Nick, Wang, Jin-Yuan, Pietilainen, Olli, Qian, Menglu, Eggan, Pierce, Cantrell, Christopher, Mok, Joanie, Kadiu, Irena, Scadden, David T., Eggan, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416879/
https://ncbi.nlm.nih.gov/pubmed/32483373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2288-7
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