C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

A hexanucleotide repeat expansion in C90RF72 is the most common genetic variant contributing to Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)(1,2). The C90RF72 mutation acts through gain and loss of function mechanisms to induce pathways implicated in neural degeneration(3–9)...

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Pubblicato in:Nature
Autori principali: Burberry, Aaron, Wells, Michael F., Limone, Francesco, Couto, Alexander, Smith, Kevin S., Keaney, James, Gillet, Gaëlle, van Gastel, Nick, Wang, Jin-Yuan, Pietilainen, Olli, Qian, Menglu, Eggan, Pierce, Cantrell, Christopher, Mok, Joanie, Kadiu, Irena, Scadden, David T., Eggan, Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416879/
https://ncbi.nlm.nih.gov/pubmed/32483373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2288-7
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