Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by collagens that can regulate cell proliferation, migration, adhesion, and remodeling of the e...

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Pubblicato in:Am J Pathol
Autori principali: Ruggeri, Jeanine M., Franco-Barraza, Janusz, Sohail, Anjum, Zhang, Yaqing, Long, Daniel, Pasca di Magliano, Marina, Cukierman, Edna, Fridman, Rafael, Crawford, Howard C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416078/
https://ncbi.nlm.nih.gov/pubmed/32339496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.020
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