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Discoidin Domain Receptors, DDR1b and DDR2, Promote Tumour Growth within Collagen but DDR1b Suppresses Experimental Lung Metastasis in HT1080 Xenografts

The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen. Using an inducible expression system in human HT1080 fibrosarcoma cells, we investigated the role of DDR1b and DDR2 on primary tumour growth and experimental lung metastase...

詳細記述

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書誌詳細
出版年:Sci Rep
主要な著者: Wasinski, Benjamin, Sohail, Anjum, Bonfil, R. Daniel, Kim, Seongho, Saliganan, Allen, Polin, Lisa, Bouhamdan, Mohamad, Kim, Hyeong-Reh C., Prunotto, Marco, Fridman, Rafael
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012844/
https://ncbi.nlm.nih.gov/pubmed/32047176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59028-w
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