Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition

Pancreatic cancer, one of the deadliest human malignancies, has a dismal 5-year survival rate of 9%. KRAS is the most commonly mutated gene in pancreatic cancer, but clinical agents that directly target mutant KRAS are not available. Several effector pathways are activated downstream of oncogenic Kr...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Brannon, Arthur, Drouillard, Donovan, Steele, Nina, Schoettle, Shadae, Abel, Ethan V., Crawford, Howard C., Pasca di Magliano, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340786/
https://ncbi.nlm.nih.gov/pubmed/32636409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67814-9
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