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Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
Pancreatic cancer, one of the deadliest human malignancies, has a dismal 5-year survival rate of 9%. KRAS is the most commonly mutated gene in pancreatic cancer, but clinical agents that directly target mutant KRAS are not available. Several effector pathways are activated downstream of oncogenic Kr...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7340786/ https://ncbi.nlm.nih.gov/pubmed/32636409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67814-9 |
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