Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis

BACKGROUND & AIMS: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance. However, its role in pancreatitis is less understood...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Halbrook, Christopher J., Wen, Hui-Ju, Ruggeri, Jeanine M., Takeuchi, Kenneth K., Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5235341/
https://ncbi.nlm.nih.gov/pubmed/28090569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2016.09.009
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