All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

PURPOSE: Extracellular accumulation of all-trans-retinaldehyde (atRAL), a highly reactive visual cycle intermediate, is toxic to cells of the outer retina and contributes to retinal and macular degenerations. However, the contribution of atRAL to retinal capillary function has not been studied. We h...

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Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Dreffs, Alyssa, Lin, Cheng-Mao, Liu, Xuwen, Shanmugam, Sumathi, Abcouwer, Steven F., Kern, Timothy S., Antonetti, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2020
Soggetti:
Retina
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415894/
https://ncbi.nlm.nih.gov/pubmed/32492112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.6.8
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