NAD+ regeneration rescues lifespan but not ataxia in a mouse model of brain mitochondrial complex I dysfunction

Mitochondrial complex I regenerates NAD+ and proton pumps for TCA cycle function and ATP production, respectively. Mitochondrial complex I dysfunction has been implicated in many brain pathologies including Leigh Syndrome and Parkinson’s disease. We sought to determine whether NAD+ regeneration or p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Metab
Egile Nagusiak: McElroy, Gregory. S., Reczek, Colleen R., Reyfman, Paul A., Mithal, Divakar S., Horbinski, Craig M., Chandel, Navdeep S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415718/
https://ncbi.nlm.nih.gov/pubmed/32574562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.06.003
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