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Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cancer cells is not fully understood. To address this, we conducted a metabolism-focused...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Kong, Hyewon, Reczek, Colleen R., McElroy, Gregory S., Steinert, Elizabeth M., Wang, Tim, Sabatini, David M., Chandel, Navdeep S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673681/
https://ncbi.nlm.nih.gov/pubmed/33148642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb7272
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