Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate

Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling pathways triggered by mitochondrial stress remodel cellular physiology and metabolism. How these signaling mechanisms contribute to neuronal dysfunction and disease is poorly understood. We find that mitochon...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Hunt, Rachel J., Granat, Lucy, McElroy, Gregory S., Ranganathan, Ramya, Chandel, Navdeep S., Bateman, Joseph M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891100/
https://ncbi.nlm.nih.gov/pubmed/31645461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201904148
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