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Revealing the activity of trimeric G-proteins in live cells with a versatile biosensor design
Heterotrimeric G-proteins (Gαβγ) are the main transducers of signals from GPCRs, thereby mediating the action of countless natural stimuli and therapeutic agents. However, there are currently no robust approaches to directly measure the activity of endogenous G-proteins in cells. Here, we describe a...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415655/ https://ncbi.nlm.nih.gov/pubmed/32634377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.020 |
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