Atypical activation of the G protein Gα(q) by the oncogenic mutation Q209P

The causative role of G protein–coupled receptor (GPCR) pathway mutations in uveal melanoma (UM) has been well-established. Nearly all UMs bear an activating mutation in a GPCR pathway mediated by G proteins of the G(q/11) family, driving tumor initiation and possibly metastatic progression. Thus, t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Maziarz, Marcin, Leyme, Anthony, Marivin, Arthur, Luebbers, Alex, Patel, Prachi P., Chen, Zhe, Sprang, Stephen R., Garcia-Marcos, Mikel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314142/
https://ncbi.nlm.nih.gov/pubmed/30352874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005291
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