Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis

Lipid metabolism in Mycobacterium tuberculosis (Mtb) relies on 34 fatty acid adenylating enzymes (FadDs) that can be grouped into two classes: fatty acyl-CoA ligases (FACLs) involved in lipid and cholesterol catabolism and long chain fatty acyl-AMP ligases (FAALs) involved in biosynthesis of the num...

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Publicado en:Eur J Med Chem
Main Authors: Baran, Marzena, Grimes, Kimberly D., Sibbald, Paul A., Fu, Peng, Boshoff, Helena I. M., Wilson, Daniel J., Aldrich, Courtney C.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415619/
https://ncbi.nlm.nih.gov/pubmed/32574901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112408
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