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Structural and functional analyses of the FAM46C/Plk4 complex
FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. Loss-of-function of FAM46C promotes cell survival of multiple myeloma, suggesting a tumor-suppressive role. FAM46C is also essential for fastening sperm head and flagellum, indispensable for male fertility. The mo...
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| 出版年: | Structure |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415566/ https://ncbi.nlm.nih.gov/pubmed/32433990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.023 |
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