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Structural and functional analyses of the FAM46C/Plk4 complex
FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. Loss-of-function of FAM46C promotes cell survival of multiple myeloma, suggesting a tumor-suppressive role. FAM46C is also essential for fastening sperm head and flagellum, indispensable for male fertility. The mo...
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| Published in: | Structure |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415566/ https://ncbi.nlm.nih.gov/pubmed/32433990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.023 |
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