FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity

Polo like kinase 4 (Plk4) is a tightly regulated serine threonine kinase that governs centriole duplication. Increased Plk4 expression, which is a feature of many common human cancers, causes centriole overduplication, mitotic irregularities, and chromosomal instability. Plk4 can also promote cancer...

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Bibliografiske detaljer
Udgivet i:Commun Biol
Main Authors: Kazazian, Karineh, Haffani, Yosr, Ng, Deanna, Lee, Chae Min Michelle, Johnston, Wendy, Kim, Minji, Xu, Roland, Pacholzyk, Karina, Zih, Francis Si-Wah, Tan, Julie, Smrke, Alannah, Pollett, Aaron, Wu, Hannah Sun-Tsi, Swallow, Carol Jane
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431843/
https://ncbi.nlm.nih.gov/pubmed/32807875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01161-3
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