Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea

In a number of mouse models of hereditary deafness, therapeutic transgene delivery to the cochlea and vestibular organs using adeno-associated viral vectors (AAVs) has shown striking rescue of hearing and balance. However, only a subset of AAV capsids have shown efficacy in transducing both inner ha...

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Bibliographic Details
Published in:Hear Res
Main Authors: Ivanchenko, Maryna V., Hanlon, Killian S., Devine, Maya K., Tenneson, Kelly, Emond, Frederick, Lafond, Jean-François, Kenna, Margaret A., Corey, David P., Maguire, Casey A.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415510/
https://ncbi.nlm.nih.gov/pubmed/32145977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2020.107930
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