AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice

The ability of recombinant adeno-associated virus (AAV) to deliver transgenes to the CNS has allowed for several advancements in the field of gene therapy to treat brain disorders. Although most AAVs do not readily cross the blood-brain barrier and transduce the CNS following peripheral administrati...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Liguore, William A., Domire, Jacqueline S., Button, Dana, Wang, Yun, Dufour, Brett D., Srinivasan, Sathya, McBride, Jodi L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838922/
https://ncbi.nlm.nih.gov/pubmed/31420242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.07.017
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