Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes

PURPOSE: Diabetic retinopathy (DR) is a leading cause of visual impairment. Müller cells in DR are dysfunctional due to downregulation of the inwardly rectifying potassium channel Kir4.1. Metformin, a commonly used oral antidiabetic drug, is known to elicit its action through 5′ adenosine monophosph...

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Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Alex, Alpha, Luo, Qianyi, Mathew, Deepa, Di, Rong, Bhatwadekar, Ashay D.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2020
Subjects:
Retinal Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415324/
https://ncbi.nlm.nih.gov/pubmed/32572457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.6.46
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