Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice

BACKGROUND/AIMS: Metabolic syndrome and type 2 diabetes are associated with some degree of acidosis. Acidosis has also been shown to upregulate renal gluconeogenesis. Whether impaired insulin or insulin-like-growth factor 1 receptor (IGF1) signaling alter this relationship is not known. Our aim was...

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Veröffentlicht in:Cell Physiol Biochem
Hauptverfasser: Aljaylani, Abdullah, Fluitt, Maurice, Piselli, Alexandra, Shepard, Blythe D., Tiwari, Swasti, Ecelbarger, Carolyn M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414422/
https://ncbi.nlm.nih.gov/pubmed/32678535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.33594/000000248
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