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Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct
To elucidate the role of the insulin receptor (IR) in collecting duct (CD), we bred mice with IR selectively deleted from CD principal cells using an aquaporin-2 promoter to drive Cre-recombinase expression. Young, adult male knockout (KO) mice had altered plasma and electrolyte homeostasis under hi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566522/ https://ncbi.nlm.nih.gov/pubmed/23195676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00161.2012 |
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