Collecting duct-specific endothelin B receptor knockout increases ENaC activity

Collecting duct (CD)-derived endothelin-1 (ET-1) acting via endothelin B (ETB) receptors promotes Na(+) excretion. Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure. Activity of the epithelial Na(+) channel (ENaC) is limiting for Na(+) reabsor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bugaj, Vladislav, Mironova, Elena, Kohan, Donald E., Stockand, James D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2012
Pynciau:
Membrane Transporters, Ion Channels and Pumps
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328904/
https://ncbi.nlm.nih.gov/pubmed/21918182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00301.2011
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