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Absence of renal enlargement in fructose‐fed proximal‐tubule‐select insulin receptor (IR), insulin‐like‐growth factor receptor (IGF1R) double knockout mice

The major site of fructose metabolism in the kidney is the proximal tubule (PT). To test whether insulin and/or IGF1 signaling in the PT is involved in renal structural/functional responses to dietary fructose, we bred mice with dual knockout (KO) of the insulin receptor (IR) and the IGF1 receptor (...

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Bibliografiske detaljer
Udgivet i:Physiol Rep
Main Authors: Li, Lijun, Byrd, Marcus, Doh, Kwame, Dixon, Patrice D., Lee, Hwal, Tiwari, Swasti, Ecelbarger, Carolyn M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357825/
https://ncbi.nlm.nih.gov/pubmed/27923977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13052
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