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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
The systematic stabilization of protein–protein interactions (PPI) has great potential as innovative drug discovery strategy to target novel and hard-to-drug protein classes. The current lack of chemical starting points and focused screening opportunities limits the identification of small molecule...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7414219/ https://ncbi.nlm.nih.gov/pubmed/32770072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17741-0 |
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