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Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase

Mevalonate diphosphate decarboxylases (MDDs) catalyze the ATP-dependent-Mg(2+)-decarboxylation of mevalonate-5-diphosphate (MVAPP) to produce isopentenyl diphosphate (IPP), which is essential in both eukaryotes and prokaryotes for polyisoprenoid synthesis. The substrates, MVAPP and ATP, have been sh...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Chun-Liang, Paul, Lake N., Mermoud, James C., Steussy, Calvin Nicklaus, Stauffacher, Cynthia V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414129/
https://ncbi.nlm.nih.gov/pubmed/32769976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17733-0
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