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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

Dynein is a microtubule motor that transports myriad cargos in various cell types and contexts. How dynein is regulated to perform these activities with spatial and temporal precision remains unclear. Human dynein is regulated by autoinhibition, whereby intermolecular contacts limit motor activity....

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Cell Biol
Päätekijät: Marzo, Matthew G., Griswold, Jacqueline M., Markus, Steven M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413593/
https://ncbi.nlm.nih.gov/pubmed/32341548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0492-1
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