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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity
Dynein is a microtubule motor that transports myriad cargos in various cell types and contexts. How dynein is regulated to perform these activities with spatial and temporal precision remains unclear. Human dynein is regulated by autoinhibition, whereby intermolecular contacts limit motor activity....
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| Publié dans: | Nat Cell Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7413593/ https://ncbi.nlm.nih.gov/pubmed/32341548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0492-1 |
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