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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity
Dynein is a microtubule motor that transports myriad cargos in various cell types and contexts. How dynein is regulated to perform these activities with spatial and temporal precision remains unclear. Human dynein is regulated by autoinhibition, whereby intermolecular contacts limit motor activity....
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| Publicado no: | Nat Cell Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7413593/ https://ncbi.nlm.nih.gov/pubmed/32341548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0492-1 |
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