Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

Intestinal stem cells (ISCs) are confined to crypt bottoms and their progeny differentiate near crypt-villus junctions. Wnt and bone morphogenic protein (BMP) gradients drive this polarity, and colorectal cancer fundamentally reflects disruption of this homeostatic signaling. However, sub-epithelial...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Stem Cell
Auteurs principaux: McCarthy, Neil, Manieri, Elisa, Storm, Elaine E., Saadatpour, Assieh, Luoma, Adrienne M., Kapoor, Varun N., Madha, Shariq, Gaynor, Liam T., Cox, Christian, Keerthivasan, Shilpa, Wucherpfennig, Kai, Yuan, Guo-Cheng, de Sauvage, Frederic J., Turley, Shannon J., Shivdasani, Ramesh A.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7412576/
https://ncbi.nlm.nih.gov/pubmed/32084389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.01.008
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires