Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages

Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics and is as...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Akbarpour, Mahzad, Lecuona, Emilia, Chiu, Stephen F., Wu, Qiang, Querrey, Melissa, Fernandez, Ramiro, Núñez-Santana, Félix L., Sun, Haiying, Ravi, Sowmya, Kurihara, Chitaru, Walter, James M., Joshi, Nikita, Ren, Ziyou, Roberts, Scott C., Hauser, Alan, Kreisel, Daniel, Li, Wenjun, Chandel, Navdeep S., Misharin, Alexander V., Mohanakumar, Thalachallour, Budinger, G.R. Scott, Bharat, Ankit
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410086/
https://ncbi.nlm.nih.gov/pubmed/32692317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135838
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