Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages

Despite the widespread use of antibiotics, bacterial pneumonias in donors strongly predispose to the fatal syndrome of primary graft dysfunction (PGD) following lung transplantation. We report that bacterial endotoxin persists in human donor lungs after pathogen is cleared with antibiotics and is as...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Akbarpour, Mahzad, Lecuona, Emilia, Chiu, Stephen F., Wu, Qiang, Querrey, Melissa, Fernandez, Ramiro, Núñez-Santana, Félix L., Sun, Haiying, Ravi, Sowmya, Kurihara, Chitaru, Walter, James M., Joshi, Nikita, Ren, Ziyou, Roberts, Scott C., Hauser, Alan, Kreisel, Daniel, Li, Wenjun, Chandel, Navdeep S., Misharin, Alexander V., Mohanakumar, Thalachallour, Budinger, G.R. Scott, Bharat, Ankit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410086/
https://ncbi.nlm.nih.gov/pubmed/32692317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135838
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