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Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy
Dominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms...
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| Publicado en: | J Clin Invest |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7410071/ https://ncbi.nlm.nih.gov/pubmed/32427588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136167 |
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