Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

Dominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bengoechea, Rocio, Findlay, Andrew R., Bhadra, Ankan K., Shao, Hao, Stein, Kevin C., Pittman, Sara K., Daw, Jil A.W., Gestwicki, Jason E., True, Heather L., Weihl, Conrad C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410071/
https://ncbi.nlm.nih.gov/pubmed/32427588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136167
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados