Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling

Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh pathway activation in adult solid tumors, such as small-cell lung cancer (SCLC), is unknown. Here we show that combined inactivation of Trp53 an...

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Publicat a:J Clin Invest
Autors principals: Cochrane, Catherine R., Vaghjiani, Vijesh, Szczepny, Anette, Jayasekara, W. Samantha N., Gonzalez-Rajal, Alvaro, Kikuchi, Kazu, McCaughan, Geoffrey W., Burgess, Andrew, Gough, Daniel J., Watkins, D. Neil, Cain, Jason E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410056/
https://ncbi.nlm.nih.gov/pubmed/32568216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132513
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