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p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic de...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7671054/ https://ncbi.nlm.nih.gov/pubmed/33235907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1805095 |
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