Chargement en cours...

p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis

Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic de...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell Oncol
Auteurs principaux: Cain, Jason E., Watkins, D. Neil
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7671054/
https://ncbi.nlm.nih.gov/pubmed/33235907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1805095
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!