ATRT-03. TARGETED CATALYTIC INHIBITION OF EZH2 SYNERGIZES WITH LOW-DOSE PANOBINOSTAT IN MALIGNANT RHABDOID TUMOR

Malignant Rhabdoid Tumor (MRT) is a rare pediatric cancer predominantly occurring in the kidney and CNS that is highly resistant to current treatment protocols. MRT is almost exclusively characterized by homozygous inactivation of SMARCB1, a critical subunit of the SWI/SNF chromatin-remodeling compl...

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Vydáno v:Neuro Oncol
Hlavní autoři: Popovski, Dean, Cochrane, Catherine, Algar, Elizabeth, Szczepny, Anette, Jayasekara, Samantha, Ashley, David, Downie, Peter, Watkins, Neil, Cain, Jason
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474967/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.002
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