A New TGF-β1 Inhibitor, CTI-82, Antagonizes Epithelial–Mesenchymal Transition through Inhibition of Phospho-SMAD2/3 and Phospho-ERK

Transforming growth factor-β1 (TGF-β1) is highly expressed in the tumor microenvironment and known to play a multifunctional role in cancer progression. In addition, TGF-β1 promotes metastasis by inducing epithelial–mesenchymal transition (EMT) in a variety of tumors. Thus, inhibition of TGF-β1 is c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biology (Basel)
Main Authors: Jeong, Ji-Hoon, Kim, Hyunhee, Park, Seung-Ho, Park, Hayeon, Jeong, Minseok, Kwak, Sungmin, Sung, Gi-Jun, Song, Ji-Hye, Na, Younghwa, Choi, Kyung-Chul
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408591/
https://ncbi.nlm.nih.gov/pubmed/32605257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology9070143
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