Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Dendrogenin A (DDA) is a mammalian cholesterol metabolite that displays potent antitumor properties on acute myeloid leukemia (AML). DDA triggers lethal autophagy in cancer cells through a biased activation of the oxysterol receptor LXRβ, and the inhibition of a sterol isomerase. We hypothesize that...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Serhan, Nizar, Mouchel, Pierre-Luc, de Medina, Philippe, Segala, Gregory, Mougel, Aurélie, Saland, Estelle, Rives, Arnaud, Lamaziere, Antonin, Despres, Gaëtan, Sarry, Jean-Emmanuel, Larrue, Clément, Vergez, François, Largeaud, Laetitia, Record, Michel, Récher, Christian, Silvente-Poirot, Sandrine, Poirot, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407291/
https://ncbi.nlm.nih.gov/pubmed/32610562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071725
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