Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

We previously synthesized dendrogenin A and hypothesized that it could be a natural metabolite occurring in mammals. Here we explore this hypothesis and report the discovery of dendrogenin A in mammalian tissues and normal cells as an enzymatic product of the conjugation of 5,6α-epoxy-cholesterol an...

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Detalhes bibliográficos
Main Authors: de Medina, Philippe, Paillasse, Michael R., Segala, Gregory, Voisin, Maud, Mhamdi, Loubna, Dalenc, Florence, Lacroix-Triki, Magali, Filleron, Thomas, Pont, Frederic, Saati, Talal Al, Morisseau, Christophe, Hammock, Bruce D., Silvente-Poirot, Sandrine, Poirot, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674249/
https://ncbi.nlm.nih.gov/pubmed/23673625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2835
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