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Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma and acute myeloid leukemia (AML). We found that DDA induced lethal autophagy in vitro and in vivo, including primary AML patient s...
Shranjeno v:
| izdano v: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5712521/ https://ncbi.nlm.nih.gov/pubmed/29199269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01948-9 |
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