Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma and acute myeloid leukemia (AML). We found that DDA induced lethal autophagy in vitro and in vivo, including primary AML patient s...

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izdano v:Nat Commun
Main Authors: Segala, Gregory, David, Marion, de Medina, Philippe, Poirot, Mathias C., Serhan, Nizar, Vergez, François, Mougel, Aurelie, Saland, Estelle, Carayon, Kevin, Leignadier, Julie, Caron, Nicolas, Voisin, Maud, Cherier, Julia, Ligat, Laetitia, Lopez, Frederic, Noguer, Emmanuel, Rives, Arnaud, Payré, Bruno, Saati, Talal al, Lamaziere, Antonin, Despres, Gaëtan, Lobaccaro, Jean-Marc, Baron, Silvere, Demur, Cecile, de Toni, Fabienne, Larrue, Clément, Boutzen, Helena, Thomas, Fabienne, Sarry, Jean-Emmanuel, Tosolini, Marie, Picard, Didier, Record, Michel, Récher, Christian, Poirot, Marc, Silvente-Poirot, Sandrine
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712521/
https://ncbi.nlm.nih.gov/pubmed/29199269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01948-9
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