Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo

Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in DAXX, which encodes a chaperone for the histone 3.3 variant, occur in 25% of pancreatic neuroendocrine tumors (PanNETs). To advance our understanding of physiological functions...

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Udgivet i:Sci Adv
Main Authors: Wasylishen, Amanda R., Sun, Chang, Moyer, Sydney M., Qi, Yuan, Chau, Gilda P., Aryal, Neeraj K., McAllister, Florencia, Kim, Michael P., Barton, Michelle C., Estrella, Jeannelyn S., Su, Xiaoping, Lozano, Guillermina
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406367/
https://ncbi.nlm.nih.gov/pubmed/32821827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba8415
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