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Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity
Gastrointestinal (GI) syndrome is a serious side effect and dose-limiting toxicity observed in patients undergoing lower-abdominal radiotherapy. Previous mouse studies show that p53 gene dosage determines susceptibility to GI syndrome development. However, the translational relevance of p53 activity...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2019
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6717251/ https://ncbi.nlm.nih.gov/pubmed/31409715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909550116 |
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