SLIT3 deficiency attenuates pressure overload–induced cardiac fibrosis and remodeling

In pulmonary hypertension and certain forms of congenital heart disease, ventricular pressure overload manifests at birth and is an obligate hemodynamic abnormality that stimulates myocardial fibrosis, which leads to ventricular dysfunction and poor clinical outcomes. Thus, an attractive strategy is...

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Foilsithe in:JCI Insight
Main Authors: Gong, Lianghui, Wang, Shuyun, Shen, Li, Liu, Catherine, Shenouda, Mena, Li, Baolei, Liu, Xiaoxiao, Shaw, John A., Wineman, Alan L., Yang, Yifeng, Xiong, Dingding, Eichmann, Anne, Evans, Sylvia M., Weiss, Stephen J., Si, Ming-Sing
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406261/
https://ncbi.nlm.nih.gov/pubmed/32644051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136852
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